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Care should be taken when using Gliclazide with medicines, which are known to alter the diabetic state or potentiate the medicines action. The hypoglycemic effect of Gliclazide may be potentiated by phenylbutazone, salicylates, sulfonamides, coumarin derivatives, monoamine oxidase inhibitors, beta-adrenergic blocking agents, ACE inhibitors, tetracycline compounds, chloramphenicol, clofibrate, disopyramide, oral forms of miconazole, cimetidine GLP-1 receptor agonists or insulin, H2-receptor antagonists, and medicines containing alcohol.
The hypoglycemic action of Gliclazide may be diminished by corticosteroids, oral contraceptives, thiazide diuretics, phenothiazines derivative, thyroid hormones and abuse of laxatives.
Warfarin should not be administered together with Gliclazide as blood clotting action may be reduced.
